ChemInform Abstract: Synthesis of (3-(Phosphonomethoxy)pyrrolidin-1-yl) Derivatives of Pyrimidines and Purines: Analogues of 2′,3′-Dideoxynucleotides

Autor:	Martin J. Parratt, Richard L. Jarvest, Michael Raymond Harnden
Rok vydání:	2010
Předmět:	chemistry.chemical_compound Chemistry Stereochemistry Hydrazine Nucleic acid Uracil General Medicine Purine metabolism Hypoxanthine Cytosine Thymine
Zdroj:	ChemInform. 24
ISSN:	0931-7597
DOI:	10.1002/chin.199301266
Popis:	Pyrrolidin-1-yl derivatives of pyrimidines and purines, incorporating the phosphonomethoxy group as a phosphate mimic, were prepared as analogues of 2′,3′-dideoxynucleotides. The heterocyclic bases uracil, thymine, cytosine, adenine and hypoxanthine were constructed upon the primary amino group of the N-aminopyrrolidine 7, which was prepared by reaction of the dibromide 6 with hydrazine.
Databáze:	OpenAIRE
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