Isolation and identification of an alkali-catalyzed hydrolysis product of nitrazepam

Autor:	A.G. Davidson, David G. Watson, S.-M. Chee, F.M. Millar
Rok vydání:	1990
Předmět:	Chromatography medicine.diagnostic_test Extraction (chemistry) Pharmaceutical Science Infrared spectroscopy Alkali metal Mass spectrometry Hydrolysis chemistry.chemical_compound chemistry Sodium hydroxide Spectrophotometry Yield (chemistry) medicine Nuclear chemistry
Zdroj:	International Journal of Pharmaceutics. 63:29-34
ISSN:	0378-5173
DOI:	10.1016/0378-5173(90)90097-n
Popis:	Spectral evidence is presented for the formation of an intermediate product during alkali hydrolysis of nitrazepam. The compound is obtained in maximum yield by heating a solution of nitrazepam in 0.1 M sodium hydroxide at 75°C for 15 min. A fast extraction technique has been developed that allows the isolation of the compound by solvent extraction with negligible hydrolysis to 2-amino-5-nitrobenzophenone. Structural elucidation by mass spectrometry, infrared spectrometry, proton magnetic resonance spectrometry, ultraviolet-visible spectrophotometry and elemental analysis has shown that the compound is N -( α -(2-amino-5-nitrophenyl)benzylidene glycine formed by cleavage of the 1,2 bond of nitrazepam.
Databáze:	OpenAIRE
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