Relationship between plasma nitric oxide concentration and insulin resistance in essential hypertension*1
| Autor: | Gerald M. Reaven, Ivana Zavaroni, Alessandra Zuccarelli, Pier Marco Piatti, Diego Ardigò, Pier Carlo Rossi, Lucilla D. Monti, Edoarda Pacetti |
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| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
business.industry Insulin medicine.medical_treatment medicine.disease Essential hypertension Nitric oxide chemistry.chemical_compound Endocrinology Insulin resistance Blood pressure chemistry Internal medicine Internal Medicine medicine Analysis of variance business Pancreatic hormone NOx |
| Zdroj: | American Journal of Hypertension. 17:549-552 |
| ISSN: | 0895-7061 |
| Popis: | Background Plasma nitric oxide (NOx) concentrations in patients with essential hypertension (EH) have been reported to be higher, lower, or no different than in normotensives. This study was initiated to determine whether these inconsistent findings were related to differences in insulin resistance. Methods Fasting plasma NOx and insulin concentrations were measured in 78 patients with EH and the relationship between these variables evaluated by regression analysis. Patients with hypertension were also divided into tertiles based on their fasting plasma insulin concentration: the highest tertile classified as insulin resistant (EH-IR) and the lowest as insulin sensitive (EH-IS). Plasma NOx concentrations were compared among these two groups and a third group of 21 normotensive, insulin resistant (N-IR) individuals by one-way ANOVA. Results Plasma insulin and NOx concentrations were correlated (r = 0.31, P Conclusions Plasma NOx concentrations are highest in those patients with EH who are also insulin resistant/hyperinsulinemic (EH-IR). Furthermore, because plasma NOx concentrations were as high in the EH-IS as in the N-IR populations, it could be speculated that plasma NOx concentrations are also modulated by EH, per se. |
| Databáze: | OpenAIRE |
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