Bioorganogermanium Chemistry: Studies on C/Si/Ge Bioisosterism

Autor:	C. Keim, T. Kornek, M. Merget, Ernst Mutschler, T. Beckerss, S. A. Wagner, Günter Lambrecht, T. Reissmann, J. Gross, M. Bernd, T. Heinrich, Reinhold Tacke
Rok vydání:	1999
Předmět:	Inorganic Chemistry chemistry Stereochemistry Organic Chemistry chemistry.chemical_element Germanium Context (language use) Biochemistry
Zdroj:	Phosphorus, Sulfur, and Silicon and the Related Elements. 150:69-87
ISSN:	1563-5325 1042-6507
DOI:	10.1080/10426509908546372
Popis:	In context with systematic investigations on C/Si/Ge bioisosterism, the following studies were carried out: (a) synthesis and pharmacological characterization of centrochiral enantiomerically pure germanium-based muscarinic antagonists; (b) synthesis and pharmacological characterization of a germanium-containing decapeptide; (c) studies on the metabolism of a germanium-based drug in the rat; (d) synthesis of centrochiral enantiomerically pure germanes using biotransformations with whole microorganisms or isolated enzymes. These investigations demonstrated that there are distinct bioisosteric relationships between the C/Si/Ge analogues studied.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4a85b17af0da1eeb9410073a539d182f https://doi.org/10.1080/10426509908546372 Zobrazit plný text záznamu