Potent Anti-Proliferation on the Colon Cancer Cell Line (HT-29) of Liposomal Formulations Entrapped with Semi-Purified Job’s Tears (Coix lacryma-jobi Linn.) Fractions
| Autor: | Kenichi Sakai, Aranya Manosroi, Jiradej Manosroi, Worapaka Manosroi, Mathukorn Sainakham, Nuttanan Sinchaipanid, Masahiko Abe |
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| Rok vydání: | 2019 |
| Předmět: |
Liposome
Metal chelating activity Materials science Sonication Cell Biomedical Engineering Bioengineering General Chemistry Pharmacology Condensed Matter Physics Microviscosity Lipid peroxidation chemistry.chemical_compound medicine.anatomical_structure chemistry Apoptosis medicine General Materials Science IC50 |
| Zdroj: | Journal of Nanoscience and Nanotechnology. 19:1996-2007 |
| ISSN: | 1533-4880 |
| Popis: | Liposomes, entrapped with Job's Tears fractions, were prepared by the supercritical carbon dioxide fluid (scCO₂) technique with and without sonication. Physical characteristics, which were the particle size, zeta potential, vesicular morphology, microviscosity and bioactivities including anti-proliferative, apoptotic and antioxidative activities of the S1L-S5L liposomal systems, were investigated. The potent anti-proliferative activity with the IC50 value of 4.44±2.31 ug/ml in a colon cancer cell (HT-29) was observed in the S5L. S5L also showed the apoptotic activity of 4.45±0.92% in an HT-29 cell. For antioxidative activities, the S3L showed the highest free radical scavenging activity and lipid peroxidation inhibition, whereas the S4L gave the highest metal chelating activity. This study has demonstrated the potent anti-proliferative activity on an HT-29 cell of the S5L liposomal formulation prepared by the scCO₂ technique which can be further developed towards a novel anticancer drug. |
| Databáze: | OpenAIRE |
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