Fuchs endothelial corneal dystrophy: current treatment recommendations and experimental surgical options
| Autor: | Isabel Dapena, Lamis Baydoun, Ester Fernández López, Gerrit R. J. Melles, Marieke Bruinsma, Fook Chang Lam |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
genetic structures Endothelium business.industry Biomedical Engineering eye diseases Surgery Transplantation Endothelial stem cell Ophthalmology medicine.anatomical_structure Descemet Stripping Endothelial Keratoplasty medicine Effective treatment sense organs Thickening Wound healing business Fuchs Endothelial Corneal Dystrophy Optometry |
| Zdroj: | Expert Review of Ophthalmology. 10:301-312 |
| ISSN: | 1746-9902 1746-9899 |
| Popis: | Fuchs endothelial corneal dystrophy is a common disorder characterized by the progressive thickening of Descemet membrane (DM), manifesting as guttae and leading to a decrease in endothelial cells and corneal clearance. Numerous studies have tried to better characterize the genetics of Fuchs endothelial corneal dystrophy, and suggest that it is a complex heterogenic disorder with an array of variants in severity and disease progression. Currently the most effective treatment for replacing diseased endothelium is endothelial keratoplasty (EK). In the last decade, EK has evolved into selective transplantation of an isolated DM and its endothelium, referred to as Descemet membrane endothelial keratoplasty (DMEK), which enables near normal anatomical and visual outcomes after surgery. Unexpected observations after DMEK, however, may bring new insights on endothelial cell wound healing, potentially allowing novel ‘non-keratoplasty’ surgical approaches like Descemet membrane endothelial transfer, endothelial ce... |
| Databáze: | OpenAIRE |
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