Enhanced insulin action following subcutaneous co-administration of insulin and C-peptide in rats
| Autor: | K. Ekberg, M. Kubota, John Wahren, Yuzo Sato, O. Khookhor, Alexander V. Chibalin |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
C-peptide business.industry Endocrinology Diabetes and Metabolism Insulin medicine.medical_treatment Glucose uptake Stimulation medicine.disease Enzyme activator chemistry.chemical_compound Endocrinology chemistry Internal medicine Diabetes mellitus Internal Medicine medicine Regular insulin business Protein kinase B |
| Zdroj: | Diabetes/Metabolism Research and Reviews. 30:124-131 |
| ISSN: | 1520-7552 |
| DOI: | 10.1002/dmrr.2471 |
| Popis: | Background This study was undertaken to examine if C-peptide (C) may interact with hexameric insulin and facilitate its disaggregation into the physiologically active monomeric form. Methods Regular insulin (I) or an insulin analogue (IA) were injected s.c. in rats together with C or its C-terminal pentapeptide (PP). I or IA and C or PP were administered either as a physical mixture or into two separate s.c. depots. Whole body glucose utilization was evaluated using the euglycemic clamp technique. Phosphorylation of Akt/PKB and GSK in liver and skeletal muscles and 86Rb+ uptake by L6 cells were measured. Results S.c. injection of a mixture of I and C or I and PP resulted in a 30–55% greater (P |
| Databáze: | OpenAIRE |
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