The agouti coat-color locus may influence brain catecholamines: Regional differences in norepinephrine and dopamine in the brains of two color-morphs of deermice (Peromyscus maniculatus)
| Autor: | V. Hayssen, S. Gunawardhana, Jerrold S. Meyer |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Pharmacology
medicine.medical_specialty Peromyscus biology digestive oral and skin physiology Immunology Central nervous system Striatum biology.organism_classification chemistry.chemical_compound medicine.anatomical_structure Endocrinology chemistry Dopamine Cerebral cortex Internal medicine Basal ganglia medicine Catecholamine Neurotransmitter medicine.drug |
| Zdroj: | Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology. 107:51-55 |
| ISSN: | 0742-8413 |
| DOI: | 10.1016/1367-8280(94)90009-4 |
| Popis: | Levels of norepinephrine (NE) and dopamine (DA) were measured by HPLC from the cortex, striatum and brain stem of agouti and nonagouti deermice ( Peromyscus maniculatus gracilis ). In the brain stem, agouti animals exhibited significantly higher NE whereas nonagouti animals had significantly higher DA. In contrast, agouti deermice had nearly twice the DA levels of nonagouti animals in both the cortex and striatum. Levels of cortical and striatal NE were similar in both color morphs, although NE in nonagouti animals was 8% higher and less variable. The variability of both NE and DA was much lower in the brain stem than in either the striatum or the cortex. This is the first evidence of a pleiotropic effect of the agouti coat-color locus on brain catecholamines. |
| Databáze: | OpenAIRE |
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