Metal-ion-assisted hydrolysis of dipeptides involving a serine residue in a neutral aqueous solutionElectronic supplementary information (ESI) available: Kinetic studies involving pH and concentration profiles of the rate constant. See http://www.rsc.org/suppdata/ob/b2/b209565c

Autor:	Morio Yashiro, Tohru Takarada, Ai Yamamura, Yoko Sonobe, Makoto Komiyama, Yuki Fujii
Rok vydání:	2003
Předmět:	Aqueous solution Chemistry Organic Chemistry Kinetics Biochemistry Combinatorial chemistry Ion Autocatalysis Metal Serine Hydrolysis Residue (chemistry) visual_art visual_art.visual_art_medium Organic chemistry Physical and Theoretical Chemistry
Zdroj:	Organic & Biomolecular Chemistry. 1:629-632
ISSN:	1477-0539 1477-0520
DOI:	10.1039/b209565c
Popis:	Dipeptides having a serine residue at the C-terminus, X-Ser, where X is an appropriate amino acid residue, were efficiently hydrolyzed in the presence of ZnCl2 at pH 7.0. The rapid hydrolysis of X-Ser is due to an autocatalysis of the hydroxy group in the serine residue, and is found to be accelerated by a metal ion, in particular by ZnCl2. Roles of the metal ion in the hydrolysis of peptides involving a serine residue, in relation to the recently reported protein cleavages, are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4a68b08c1ba402192bcdfe0ca7ae1541 https://doi.org/10.1039/b209565c Zobrazit plný text záznamu