An emulsion preparation for novel micro-porous polymeric hemi-shells
| Autor: | Kersch Naidoo, Avashnee Chetty, Heidi Rolfes, Wim Richter, Kim Easton, Sean Moolman, R.W.N. Nilen |
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| Rok vydání: | 2008 |
| Předmět: |
chemistry.chemical_classification
Materials science Mechanical Engineering Gas evolution reaction Aqueous two-phase system Polymer Condensed Matter Physics Polyvinyl alcohol Solvent chemistry.chemical_compound chemistry Chemical engineering Mechanics of Materials Emulsion Polycaprolactone Particle General Materials Science Composite material |
| Zdroj: | Materials Letters. 62:252-254 |
| ISSN: | 0167-577X |
| DOI: | 10.1016/j.matlet.2007.05.012 |
| Popis: | A modified oil-in-water (O/W) emulsion process was developed to produce novel micro-porous hemi-spherical polycaprolactone (PCL) micro-particles called “hemi-shells”. By addition of a porogen such as sodium bicarbonate (NaHCO 3 ) into the PCL-dichloromethane (DCM) oil phase and emulsification in an acidic polyvinyl alcohol (PVA) aqueous phase, micro-porous hemi-shells formed as solvent evaporated. CO 2 gas evolution from the porogen created particles with an externally micro-porous shell and a large internal cavity. The hemi-shells were characterized by SEM and optical microscopy. The number-average particle yield in the 50–200 μm range was 84%. The number-average hemi-shell yield in the same size range was 41%. These novel micro-particles have potential applications in tissue engineering and drug delivery. |
| Databáze: | OpenAIRE |
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