Antinociceptive and antioxidant activity of Calliandra umbellifera Benth
| Autor: | Camila Holanda de Albuquerque, Diogo Vilar da Fonsêca, Maria de Fátima Agra, Juliana de Medeiros Gomes, Josean Fechine Tavares, Tainá Souza Silva, Marcelo Sobral da Silva, Reinaldo Nóbrega de Almeida |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pharmacology chemistry.chemical_classification Calliandra Antioxidant Traditional medicine biology DPPH medicine.medical_treatment Flavonoid Pharmaceutical Science biology.organism_classification 01 natural sciences 0104 chemical sciences 010404 medicinal & biomolecular chemistry 03 medical and health sciences Acetic acid chemistry.chemical_compound 030104 developmental biology Nociception chemistry In vivo medicine EC50 |
| Zdroj: | African Journal of Pharmacy and Pharmacology. 10:892-899 |
| ISSN: | 1996-0816 |
| DOI: | 10.5897/ajpp2016.4683 |
| Popis: | The genus, Calliandra is popularly used for renal pain, cystitis, prostate inflammation, fever and toothache. This study aimed at investigating the antinociceptive activity of methanolic crude extract (MCE) of Calliandra umbellifera, regarding chemical (acetic acid, formalin and glutamate tests) of nociception (in vivo) and the methanolic extract and hidrobutanolic phase (HBF) antioxidant activity by the 2,2-diphenyl-1-picril-hidrazil (DPPH) method, besides determination of the content of phenolic compounds and flavonoids (in vitro). The pre-treatment with the MCE (100, 200 and 300 mg/kg, p.o) was able to reduce the number of abdominal contortions (p |
| Databáze: | OpenAIRE |
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