The Biological Activity of Designer Drugs from the Group of Synthetic Opioids

Autor:	Vladimir L. Rejniuk, A. I. Golovko, Ju. Ju. Ivnitsky, M. B. Ivanov, V. K. Kozlov
Rok vydání:	2021
Předmět:	0106 biological sciences 0301 basic medicine Synthetic opioid Opium alkaloids medicine.drug_class Biological activity General Medicine Biology Bioinformatics 010603 evolutionary biology 01 natural sciences Designer drug 03 medical and health sciences 030104 developmental biology medicine
Zdroj:	Biology Bulletin Reviews. 11:186-197
ISSN:	2079-0872 2079-0864
DOI:	10.1134/s2079086421020031
Popis:	Information on the biological activity of designer synthetic opioids is presented. The classifications of such agents are reviewed. Comparisons of synthetic opioids and opium alkaloids are given for analgesic and addictive effects and the ability to cause respiratory depression. The unusual biological activity of designer opioids is based on their high affinity for µ-opioid receptors, pronounced agonistic properties, and the ease of their ability to cross the blood-brain barrier. The presented biological characteristics allow designer synthetic opioids to be classified as the most dangerous drugs in illicit traffic.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4a59b03103cff91dd6f22176f8f7ff2d https://doi.org/10.1134/s2079086421020031 Zobrazit plný text záznamu Full text from SpringerLink