Severity of infectious mononucleosis correlates with the frequency of crossreactive influenza A/Epstein Barr virus-specific CD8+ T cells (HUM4P.301)
| Autor: | Liisa Selin, Levi Watkin, Anna Gil, Rabinarayan Mishra, Katherine Luzuriaga, Nuray Aslan |
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| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 194:122.8-122.8 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.194.supp.122.8 |
| Popis: | During EBV-associated infectious mononucleosis (IM) IAV-specific crossreactive memory T cells are activated and play a role in disease severity. In HLA-A2+ IM patients, influenza M158 (IAV-M1)-specific CD8 memory T cell responses crossreacted with two different EBV lytic epitopes, BMLF1280 (17/29) and BRLF1109 (19/20). Disease severity of IM directly correlated with significantly increased frequencies of crossreactive IAV-M1/EBV-BMLF1, IAV-M1, and EBV-BMLF1 specific CD8 cells, and with mean viral load over the first 5 weeks of infection. Disease severity did not correlate with BRLF1 or M1/BRLF1 crossreactive responses. When severity of IM was scored and patients were assigned to either mild or severe groups, disease severity correlated with specific TCR Vb usage in IAV-M1 population suggesting that TcR selection is driving disease outcome. Consistent with crossreactive responses driving increased immunopathology was the observation that tetramer-sorted crossreactive responses had completely altered immune response signatures than cognate responses by gene array. These results suggest that T cell crossreactivity impacts T cell selection and function and ultimately disease outcome. Insights on these issues are important for the intelligent design of vaccines and to develop therapeutic interventions for virally induced disease (NIHAI49320). |
| Databáze: | OpenAIRE |
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