An open-label phase 1 trial of the safety and efficacy of daily subcutaneous SPL-108 injections when used in combination with paclitaxel in patients with platinum-resistant, CD44+, advanced ovarian epithelial cancer

Autor:	Eugenia Girda, David L. Nelson, Lorna Rodriguez-Rodriguez, Malcolm Finlayson, Aliza L. Leiser, Ruth Stephenson, Alexandre Buckley de Meritens, Michael H. Silverman
Rok vydání:	2018
Předmět:	0301 basic medicine Oncology Cancer Research medicine.medical_specialty endocrine system diseases medicine.medical_treatment Disease 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine In patient Platinum resistant Chemotherapy biology business.industry CD44 medicine.disease female genital diseases and pregnancy complications 030104 developmental biology Paclitaxel chemistry 030220 oncology & carcinogenesis biology.protein Open label Ovarian cancer business
Zdroj:	Journal of Clinical Oncology. 36:TPS5608-TPS5608
ISSN:	1527-7755 0732-183X
Popis:	TPS5608Background: Ovarian cancer often presents in advanced stages and is treated with platinum-based chemotherapy. However, many patients develop platinum-resistant disease with either failing to...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4a552396a2b420b58397cc7089105f79 https://doi.org/10.1200/jco.2018.36.15_suppl.tps5608 Zobrazit plný text záznamu