Comparison of clinicopathological features of patients with hepatocellular carcinoma seropositive for alpha-fetoprotein alone and those seropositive for des-gamma-carboxy prothrombin alone1

Autor: Hiroaki Okuda, Naoaki Hayashi, Akiko Saito, Kazuko Takatsu, Masayuki Nakano, Ken Takasaki, Toshimi Nakanishi, Masakazu Yamamoto
Rok vydání: 2001
Předmět:
Zdroj: Journal of Gastroenterology and Hepatology. 16:1290-1296
ISSN: 1440-1746
0815-9319
DOI: 10.1046/j.1440-1746.2001.02610.x
Popis: Background: There has been no comparative study of the clinicopathological features of HCC patients who are seropositive for α-fetoprotein (AFP) alone and those who are seropositive for des-γ-carboxy prothrombin (DCP) alone. The authors, thus, performed this comparative study. Methods: The clinicopathological features of patients with solitary hepatocellular carcinoma (HCC), who underwent a hepatectomy were compared among the four below groups according to the seropositivity of AFP and DCP: group A, seronegative for both AFP below 20 ng/mL and DCP below 40 mAU/mL; group B, seropositive for AFP above 100 ng/mL and seronegative for DCP; group C, seronegative for AFP and seropositive for DCP above 100 mAU/mL; and group D, seropositive for both AFP and DCP. Results: Group B patients showed a higher incidence of HCC with an indistinct margin, and a somewhat higher incidence of small HCC less than 2 cm in greatest dimension compared with group C patients. By contrast, group C patients had a higher frequency of HCC with a distinct margin compared with that of an indistinct margin, large tumors more than 3 cm compared with that of small tumors less than 2 cm, and a somewhat higher frequency of moderately to poorly differentiated HCC compared with that of well-differentiated HCC. Our HCC cases showed advanced clinicopathological features in the order of group C, group B and group A. Groups C and D patients showed similar characteristics. Conclusions: Hepatocellular carcinoma patients who were seropositive for AFP alone demonstrated clinicopathological features of less advanced HCC compared with those who were seropositive for DCP alone.
Databáze: OpenAIRE
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