Toxicokinetics of titanium dioxide (TiO2) nanoparticles after inhalation in rats
| Autor: | Alessandra M. Serventi, Sami Haddad, Igor Pujalté, Denis Dieme, Michèle Bouchard |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Inhalation exposure medicine.medical_specialty Kidney Lung Inhalation Chemistry Mucociliary clearance 030111 toxicology 02 engineering and technology General Medicine respiratory system 021001 nanoscience & nanotechnology Toxicology medicine.disease_cause 03 medical and health sciences Endocrinology medicine.anatomical_structure Internal medicine Anesthesia medicine Toxicokinetics Lymph 0210 nano-technology Oxidative stress |
| Zdroj: | Toxicology Letters. 265:77-85 |
| ISSN: | 0378-4274 |
| DOI: | 10.1016/j.toxlet.2016.11.014 |
| Popis: | This study focused on the generation of aerosols of titanium dioxide (TiO2) nanoparticles (NPs) and their disposition kinetics in rats. Male Sprague-Dawley rats were exposed by inhalation to 15mg/m3 of anatase TiO2 NPs (∼20nm) during 6h. Rats were sacrificed at different time points over 14days following the onset of inhalation. Ti levels were quantified by ICP-MS in blood, tissues, and excreta. Oxidative damages were also monitored (MDA). Highest tissue levels of Ti were found in lungs; peak values were reached only at 48h followed by a progressive decrease over 14days, suggesting a persistence of NPs at the site-of-entry. Levels reached in blood, lymph nodes and other internal organs (including liver, kidney, spleen) were circa one order of magnitude lower than in lungs, but the profiles were indicative of a certain translocation to the systemic circulation. Large amounts were recovered in feces compared to urine, suggesting that inhaled NPs were eliminated mainly by mucociliary clearance and ingested. TiO2 NPs also appeared to be partly transferred to olfactory bulbs and brain. MDA levels indicative of oxidative damage were significantly increased in lungs and blood at 24h but this was not clearly reflected at later times. Translocation and clearance rates of inhaled NPs under different realistic exposure conditions should be further documented. |
| Databáze: | OpenAIRE |
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