Oral Delivery of Probiotics Using pH-Sensitive Tablets
| Autor: | Sang-Kee Kang, Chong-Su Cho, Yun-Jaie Choi, Geon Goo Han, Zhong-Shan Hong, Hui-Shan Li, Dae-Duk Kim, Jin-Duck Bok, Bijay Singh, Tao Jiang |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Drug compounding Chemistry General Medicine 010501 environmental sciences 01 natural sciences Applied Microbiology and Biotechnology Intestinal fluid Dosage form 03 medical and health sciences 030104 developmental biology Oral administration Food science Neutral ph 0105 earth and related environmental sciences Biotechnology |
| Zdroj: | Journal of Microbiology and Biotechnology. 27:739-746 |
| ISSN: | 1738-8872 1017-7825 |
| DOI: | 10.4014/jmb.1606.06071 |
| Popis: | As alternatives to antibiotics in livestocks, probiotics have been used, although most of them in the form of liquid or semisolid formulations, which show low cell viability after oral administration. Therefore, suitable dry dosage forms should be developed for livestocks to protect probiotics against the low pH in the stomach such that the products have higher probiotics survivability. Here, in order to develop a dry dosage forms of probiotics for poultry, we used hydroxypropyl methylcellulose phthalate 55 (HPMCP 55) as a tablet-forming matrix to develop probiotics in a tablet form for poultry. Here, we made three different kinds of probiotics-loaded tablet under different compression forces and investigated their characteristics based on their survivability, morphology, disintegration time, and kinetics in simulated gastrointestinal fluid. The results indicated that the probiotics formulated in the tablets displayed higher survival rates in acidic gastric conditions than probiotics in solution. Rapid release of the probiotics from the tablets occurred in simulated intestinal fluid because of fast swelling of the tablets in neutral pH. As a matrix of tablet, HPMCP 55 provided good viability of probiotics after 6 months under refrigeration. Moreover, after oral administration of probiotics-loaded tablets to chicken, more viable probiotics were observed, than with solution type, through several digestive areas of chicken by the tablets. |
| Databáze: | OpenAIRE |
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