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Microfluidic chips for the separation of circulating tumor cells (CTCs) from a blood sample are an effective tool that can be used in clinical practice for the diagnostics of disease and assistance in choosing the most adequate therapy adapted to the specific patient and tumor type. The separation of CTCs in a microfluidic chip based on physical properties such as size, shape, and deformability is a promising technique because it ensures that cells are isolated under higher flow rates while remaining viable and ready for further analysis. Numerical simulations can provide additional information about the behavior of cells in complex microchannels. Tracking the motion of individual cells in a microfluidic chip is enabled with the numerical model proposed in this chapter. This model can be used to analyze different design strategies, improve microfluidic chip design, and precisely define the most optimal parameters that ensure high capture efficiency. |
