Immunotoxicity of aflatoxin M1: as a potent suppressor of innate and acquired immune systems in a subacute study
| Autor: | Faezeh Vahdati Hassani, Amir Hosein Jafarian, Bamdad Riahi Zanjani, Kobra Shirani, John P. Giesy, Gholamreza Karimi, Mahmoud Mahmoudi |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Hemagglutination medicine.medical_treatment Spleen 03 medical and health sciences 0404 agricultural biotechnology Immune system In vivo medicine Nutrition and Dietetics Innate immune system biology business.industry 04 agricultural and veterinary sciences Acquired immune system 040401 food science 030104 developmental biology medicine.anatomical_structure Cytokine Immunoglobulin M Immunology biology.protein business Agronomy and Crop Science Food Science Biotechnology |
| Zdroj: | Journal of the Science of Food and Agriculture. 98:5884-5892 |
| ISSN: | 0022-5142 |
| DOI: | 10.1002/jsfa.9240 |
| Popis: | Although, to date, there have been several in vitro and in vivo studies of immunomodulatory effects of aflatoxin M1 (AFB1 ), little is known about the effect of AFM1 on various aspects of innate and acquired immunity. In the present study, AFM1 was administered intraperitoneally, at doses of 25 and 50 μg kg-1 , body mass for 28 days and various immunological parameters were measured.; Results: Several parameters related to immune function were suppressed: organ mass, cellularity of spleen, proliferation response to lipopolysaccaride and phytohemagglutinin-A, hemagglutination titer, delayed type of hypersensitivity response, spleen cell subtypes, serum hemolytic activity, serum immunoglobulin G level and cytokine production. AFM1 did not cause changes in body mass, hematological parameters or the concentration of immunoglobulin M in blood serum.; Conclusions: Overall, the data suggested that AFM1 suppressed innate and acquired immunity. Therefore, with respect to consumer safety, it is extremely important to further control the level of AFM1 in milk, and this should be considered as a precedence for risk management actions. © 2018 Society of Chemical Industry.; © 2018 Society of Chemical Industry. |
| Databáze: | OpenAIRE |
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