Flow-injection potentiometric and conductometric determination of papaverine hydrochloride in the parent substance and a related pharmaceutical preparation

Autor:	S. M. Hamed, Rasha M. El-Nashar, Nour T. Abdel-Ghani, Mahmoud S. Rizk
Rok vydání:	2007
Předmět:	Pharmacology Papaverine Chromatography Chemistry Potentiometric titration Solubility equilibrium chemistry.chemical_compound Membrane Reaction rate constant Drug Discovery medicine Phosphomolybdic acid Titration Phosphotungstic acid medicine.drug
Zdroj:	Pharmaceutical Chemistry Journal. 41:447-454
ISSN:	1573-9031 0091-150X
Popis:	Papaverine (Pap) ion-selective plastic membrane electrodes based on ion associates of papaverine with phosphotungstic acid (Pap-PTA) and phosphomolybdic acid (Pap-PMA) were prepared and fully characterized in terms of membrane composition, life span, pH, and temperature. The proposed electrodes were applied to potentiometeric determination of papaverine in the parent substance and a related pharmaceutical preparation under batch and flow-injection analysis conditions. In addition, conductometric titrations were used for the assay of papaverine in the parent substance and the related pharmaceutical preparation. The selectivity of electrodes with respect to a large number of foreign inorganic cations, amino acids, and sugars was tested. The solubility product of the ion associate and the rate constant of the precipitation reaction leading to the ion associate formation were determined conductometrically.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4a3a1cfc2bb52ebf91c591cfe898f56a https://doi.org/10.1007/s11094-007-0098-y Zobrazit plný text záznamu Plný text ve formátu PDF