Gene Activation Is Introduced as Cell Protection Mechanism Against Gamma Ray Irradiation

Autor:	Mostafa Rezaei-Tavirani, Babak Arjmand, Mostafa Hamdieh, Mohammad Rostami-Nejad, Abdolrahim Nikzamir, Zahra Razzaghi
Rok vydání:	2020
Předmět:	Regulation of gene expression CENPA biology Cell growth business.industry Urology CENPF Dermatology medicine.disease_cause Jurkat cells Cell biology Nephrology Gene expression biology.protein Medicine Dentistry (miscellaneous) Orthopedics and Sports Medicine Surgery business Carcinogenesis Gene
Zdroj:	Journal of Lasers in Medical Sciences. 11:S80-S84
ISSN:	2228-6721 2008-9783
Popis:	Introduction: Gamma radiation is accompanied by prominent biological effects and damages. Cell proliferation and tumorigenesis are highlighted as the main resulted effects of gamma radiation on cultured cells. This study aims to assess the dysregulated mode of gene function after gamma radiation in human Jurkat cells. Methods: Six gene expression profiles from Gene Expression Omnibus (GEO) were analyzed by GEO2R to find the significant differentially expressed genes (DEGs) via gamma radiation. Action map analysis was applied to screen the query DEGs. Results: Among 108 study genes, 20 critical DEGs including AURKA, AURKB, BORA, CCNB1, CCNB2, CCNF, CDC20, CDCA8, CENPA, CENPE, CENPF, KIF18A, KIF20A, KIF23, BUB1, DLGAP5, ECT2, PLK1, SGO2, and TPX2 were introduced as down-regulated genes by the gamma ray. Conclusion: Activators of the introduced critical genes may be the cell protector against gamma radiation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4a399828f4058e4c55371364a29541df https://doi.org/10.34172/jlms.2020.s13 Zobrazit plný text záznamu Plný text ve formátu PDF