Three-Component Mannich Couplings En Route to Substituted Aminophenol and Benzoxazine Derivatives

Autor:	Ana M. Martins, Sónia Barroso, Ana M. Coelho, Ana M. Abreu, Ana C. Araújo, Nuno Maulide
Rok vydání:	2010
Předmět:	Steric effects Hydrolysis chemistry.chemical_compound Chemistry Organic Chemistry Organic chemistry Stereoselectivity Phenols
Zdroj:	Synlett. 2010:2425-2428
ISSN:	1437-2096 0936-5214
Popis:	The three-component Mannich coupling of phenols, primary amines, and aldehydes was investigated. Unexpectedly, benzoxazine products were obtained in most cases, even in instances where steric hindrance would seem to militate against benzoxazine formation. The stereoselective synthesis of such benzoxazines, their hydrolysis to aminophenol derivatives, and the mechanisms involved are presented and discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4a38239a230af1e28085de84e3d16144 https://doi.org/10.1055/s-0030-1258047 Zobrazit plný text záznamu