781-P: Glycemic Response to Diabetes-Specific Formulas and Associations with Sex, Age, Body Mass Index, and A1c in Adults with Type 2 Diabetes: A Subgroup Analysis
| Autor: | Carolyn J. Alish |
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| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Diabetes. 68 |
| ISSN: | 1939-327X 0012-1797 |
| DOI: | 10.2337/db19-781-p |
| Popis: | Background: Diabetes-specific formulas (DSF) are designed to improve glycemic control in people with diabetes. We evaluated the relationships between study participant characteristics and impact on postprandial glycemic (PPG) response of Glucerna® formulas, other DSF, and typical foods consumed by adults with type 2 diabetes. Methods: Fasting plasma glucose and PPG response data were extracted for analysis from 10 randomized, placebo-controlled, crossover studies conducted between 2003 and 2010. Interventions included Glucerna® formulas (Abbott Nutrition, Columbus, Ohio, U.S.), other non-Abbott DSF, and typical foods (oatmeal and a standard high carbohydrate breakfast). First period data for maximal change from baseline for glucose were analyzed for sex, body mass index (BMI), and A1c. Results: A total of 505 participants were included in the analysis (median age, 59 years; median BMI, 31.7 kg/m2; and median A1c, 7.3%). Compared to other DSF and to food, Glucerna products elicited an improved PPG response (mean + standard error of the mean. Glucerna: 2.18 + 0.10 mmol/L; other DSF: 3.38 + 0.24 mmol/L, p 7.3%, regardless of treatment (p=0.05). Conclusions: Glucerna products elicited a better PPG response compared to other DSF and selected foods in adults with type 2 diabetes irrespective of sex, age or BMI. There appears to be variability in PPG responses to Glucerna and other DSF in overweight and obese adults with type 2 diabetes; this variability could be due to differences in nutrient composition and ingredients. Disclosure C.J. Alish: Employee; Self; Abbott Laboratories. |
| Databáze: | OpenAIRE |
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