Nickel(0)-mediated [2+2+1] cyclization reaction of chromium carbene complexes and internal alkynes

Autor:	Luis A. López, José Barluenga, Miguel Tomás, Lorena Riesgo, Pablo Barrio
Rok vydání:	2006
Předmět:	chemistry.chemical_classification Transition metal carbene complex Aryl Organic Chemistry Regioselectivity chemistry.chemical_element Biochemistry Medicinal chemistry chemistry.chemical_compound Chromium chemistry Intramolecular force Drug Discovery Indene Carbene Alkyl
Zdroj:	Tetrahedron. 62:7547-7551
ISSN:	0040-4020
DOI:	10.1016/j.tet.2006.03.117
Popis:	Alkyl, aryl, and heteroaryl chromium Fischer carbene complexes undergo Ni(0)-mediated [2+2+1] cyclization reaction with internal unactivated and electron-poor internal alkynes to yield highly substituted cyclopentadienes with complete regioselectivity in most cases. The intramolecular version of this cyclization has been accomplished with 1,8-diphenyl-1,7-octadiyne to produce indene derivatives. This three-component [2+2+1] cyclization represents a very uncommon process in the chemistry of Fischer carbene complexes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4a1dabb6ce15a9dcb65feb6080cca7ae https://doi.org/10.1016/j.tet.2006.03.117 Zobrazit plný text záznamu Full Text from ScienceDirect