Sphenoid sinus malignancies: a population-based comprehensive analysis

Autor:	Pariket M. Dubal, Soly Baredes, Oliver Y. Chin, Tapan D. Patel, James K. Liu, Jean Anderson Eloy, Kristen A. Echanique, Ritam Ghosh
Rok vydání:	2016
Předmět:	Pathology medicine.medical_specialty education.field_of_study business.industry Incidence (epidemiology) Population Squamous Cell Neoplasm Cancer Population based medicine.disease Dermatology stomatognathic diseases 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Epidemiology Immunology and Allergy Medicine Histopathology 030223 otorhinolaryngology business education Sinus (anatomy)
Zdroj:	International Forum of Allergy & Rhinology. 6:752-759
ISSN:	2042-6976
Popis:	Background Sinonasal malignancies are rare, representing less than 1% of all cancers, with the sphenoid sinus accounting for 1% to 2% of these cases. Sphenoid sinus malignancies exhibit very poor outcomes. There is a paucity of literature describing their histopathological features, incidence trends, treatment, and survival. We seek to elucidate these factors using a national population-based resource. Methods The Surveillance, Epidemiology, and End Results (SEER) database was used to identify malignant sphenoid sinus tumors. The results were analyzed for demographics, incidence, and clinicopathologic trends. Survival was calculated using Kaplan-Meier analysis. Results The search identified 472 cases. The mean and median age at diagnosis was 60.0 years. Males represented 54.9% of cases. By race/ethnicity, 82.4% were white and 8.5% were black. The four most common histopathologies were squamous cell neoplasms (29.4%), adenocarcinomas (14.4%), non-Hodgkin's mature B-cell lymphomas (13.1%), and unspecified epithelial neoplasms (11.0%). The overall incidence from 2000 to 2012 was 0.030 per 100,000. Kaplan-Meier analysis demonstrated an overall 5-year disease-specific survival (DSS) of 48.1%. Of the most common histopathological subtypes, 5-year DSS was best for mature B-cell NHL (64.0%) and worst for unspecified epithelial neoplasms (25.6%). Conclusion Sphenoid sinus malignancies are rare, with high prevalence in white males. The most common histopathology is squamous cell neoplasms. They exhibit significant locoregional extension. Of the common sphenoid sinus malignant subtypes, 5-year DSS is best for mature B-cell NHL and worst for unspecified epithelial neoplasms.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4a17afea79c49a0ae756a334c839c1b7 https://doi.org/10.1002/alr.21733 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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