The Proportion of Prostate-specific Antigen (PSA) Complexed to α1-Antichymotrypsin Improves the Discrimination between Prostate Cancer and Benign Prostatic Hyperplasia in Men with a Total PSA of 10 to 30 μg/L
| Autor: | Francisco España, César D. Vera, Silvia Navarro, Jose M Alapont, Amparo Estellés, Justo Aznar, Manuel Martinez, Juan F. Jiménez-Cruz, Montserrat Royo |
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| Rok vydání: | 2002 |
| Předmět: |
Gynecology
medicine.medical_specialty Receiver operating characteristic Adenoma business.industry Biochemistry (medical) Clinical Biochemistry Urology Hyperplasia urologic and male genital diseases medicine.disease Confidence interval Prostate-specific antigen Prostate cancer medicine.anatomical_structure Prostate medicine Prospective cohort study business |
| Zdroj: | Clinical Chemistry. 48:1251-1256 |
| ISSN: | 1530-8561 0009-9147 |
| DOI: | 10.1093/clinchem/48.8.1251 |
| Popis: | Background: The aim of this study was to assess the diagnostic accuracy of the proportion of prostate-specific antigen (PSA) complexed to α1-antichymotrypsin (PSA-α1ACT:PSA ratio) in the differential diagnosis of prostate cancer (CaP) and benign prostatic hyperplasia (BPH) in men with total PSA of 10–30 μg/L. Methods: We used our immunoassays (ELISAs) for total PSA and PSA-α1ACT complex to study 146 men. In 123, total PSA was between 10 and 20 μg/L; 66 of these had CaP and 57 BPH. In 23 men, total PSA was between 20 and 30 μg/L; 14 of these had CaP and 9 BPH. We calculated the area under the ROC curves (AUC) for total PSA, PSA-α1ACT complex, and PSA-α1ACT:PSA ratio, and determined the cutoff points that gave sensitivities approaching 100%. Results: In the total PSA range between 10 and 20 μg/L, the AUC was significantly higher for the PSA-α1ACT:PSA ratio (0.850) than for total PSA (0.507) and PSA-α1ACT complex (0.710; P Conclusions: The diagnostic accuracy of the PSA-α1ACT:PSA ratio persists at high total PSA concentrations, increasing the specificity of total PSA. Prospective studies with large numbers of patients are needed to assess whether the ratio of PSA-α1ACT to total PSA is a useful tool to avoid unnecessary prostatic biopsy in patients with a total PSA >10 μg/L. |
| Databáze: | OpenAIRE |
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