Crystallization Behavior of Polymorphic Mixtures of MPPO

Autor:	Yoshitaka Nakata, Youko Kiyosawa, Masakuni Matsuoka, Kooji Kagara
Rok vydání:	2009
Předmět:	Supersaturation X-ray absorption spectroscopy Aqueous solution Chemistry Organic Chemistry law.invention Solvent Chemical engineering law Organic chemistry Composition (visual arts) Seeding Solvent composition Physical and Theoretical Chemistry Crystallization
Zdroj:	Organic Process Research & Development. 13:1364-1369
ISSN:	1520-586X 1083-6160
Popis:	4-(1-(2-(3-Methoxyphenethyl)phenoxy)-3-(dimethylamino)propan-2-yloxy)-4-oxobutanoic acid (MPPO), a serotonin receptor blocker, is known to have two polymorphs, Form A and Form B. Crystallization of MPPO was carried out from aqueous 2-butanone solutions by the further addition of 2-butanone as a poor solvent and by cooling to determine the operating conditions, in particular, the seeding effect under which polymorphic mixtures of desired compositions were produced. Seed particles were prepared by comminuting both polymorphs and mixing them at given compositions XAs. The product polymorphic compositions (XAp) were well controlled by the seed composition as well as by the initial solvent composition (w) and seeding temperature in such a way that XAp increased as the supersaturation at the moment of seeding decreased. In addition, size-dependent product compositions were analyzed to reveal the crystallization behavior of the polymorphs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4a0a7e63f491e84c74453353ba453ef2 https://doi.org/10.1021/op900220m Zobrazit plný text záznamu