Formal synthesis of (−)-stemoamide using a useful epimerization at C-8

Autor:	Kishor R. Harale, Subhash P. Chavan, Rupesh L. Gawade, Vedavati G. Puranik
Rok vydání:	2012
Předmět:	Formal synthesis chemistry.chemical_compound Allylic rearrangement Ring-closing metathesis Chemistry Stereochemistry Organic Chemistry Drug Discovery Organic chemistry Epimer Pyroglutamic acid Biochemistry Stemoamide
Zdroj:	Tetrahedron Letters. 53:2647-2650
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2012.03.054
Popis:	The formal synthesis of (−)-stemoamide was achieved starting from l -pyroglutamic acid. The key steps used are the allylation using BF3·OEt2, ring closing metathesis, allylic oxidation and a novel epimerization at C8.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::49ff78621d98f7a26b8815034dac6c2e https://doi.org/10.1016/j.tetlet.2012.03.054 Zobrazit plný text záznamu Full Text from ScienceDirect