Modified Liquid Chromatographic Assay for Diltiazem and Metabolites in Human Plasma
| Autor: | T. E. Jones, N. C. Saccoia, Raymond G. Morris |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Chromatography
Metabolite Clinical Biochemistry Pharmaceutical Science Metabolism Biochemistry High-performance liquid chromatography Analytical Chemistry chemistry.chemical_compound chemistry Renal transplant Human plasma Blood plasma medicine Diltiazem Quantitative analysis (chemistry) medicine.drug |
| Zdroj: | Journal of Liquid Chromatography & Related Technologies. 19:2385-2394 |
| ISSN: | 1520-572X 1082-6076 |
| DOI: | 10.1080/10826079608014024 |
| Popis: | Diltiazem (DTZ) is an anti-hypertensive and anti-anginal agent which is also used clinically as a metabolic inhibitor to reduce cyclosporin-A metabolism. The present communication describes an HPLC/UV method for measuring DTZ and 3 of its major metabolites. This method has a LOQ below 2.5 μg/L and within run CV's ranging from 11.3 to 1.9% at concentrations of 2.5 and 100 μg/L, and between-run CV's ranging from 10.5 to 4.9% at concentrations of 75 and 350 μg/L, respectively. The method has been applied successfully to 11 renal transplant recipients taking a variety of other drugs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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