Hyperpolarization-activated I h pacemaker channel in the mammalian brain
| Autor: | O. L. Segal, A. S. Bazyan |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Thalamic reticular nucleus
Chemistry Protein subunit Cortical neurons Hyperpolarization (biology) Somatosensory system Mammalian brain medicine.disease Biochemistry Cellular and Molecular Neuroscience Epilepsy medicine.anatomical_structure Reticular connective tissue medicine Molecular Biology Neuroscience |
| Zdroj: | Neurochemical Journal. 4:241-251 |
| ISSN: | 1819-7132 1819-7124 |
| DOI: | 10.1134/s181971241004001x |
| Popis: | In this review we describe the molecular structure of the hyperpolarization-activated cAMP-dependent Ih, or HCN, pacemaker channel. We discuss the channel functions and its subunit composition. Also, we hypothesize that spike-wave discharges in absence epilepsy are caused by these Ih channels located on the neurons of the thalamic reticular nucleus and layers three, four, and five of the somatosensory cortex. We describe the role of Ih channels on reticular and cortical neurons in normal behavior. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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