Manganese(ii ) complexes stimulate antitumor immunity via aggravating DNA damage and activating the cGAS-STING pathway
| Autor: | Linxiang Cai, Ying Wang, Yayu Chen, Hanhua Chen, Tao Yang, Shuren Zhang, Zijian Guo, Xiaoyong Wang |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Chemical Science. 14:4375-4389 |
| ISSN: | 2041-6539 2041-6520 |
| DOI: | 10.1039/d2sc06036a |
| Popis: | Mn complexes act as breakers of DNA to induce DSB, as inhibitors of HDAC and PARP to impede DNA repair, and as activators of the cGAS-STING pathway to trigger immune responses, thereby stimulating T cells to suppress tumor growth in a synergic mechanism. |
| Databáze: | OpenAIRE |
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