Mechanical resonant immunospecific biological detector
Autor: | David A. Czaplewski, Harold G. Craighead, Pavel Neuzil, Carl A. Batt, Bojan Ilic, C. Campagnolo |
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Rok vydání: | 2000 |
Předmět: | |
Zdroj: | Applied Physics Letters. 77:450-452 |
ISSN: | 1077-3118 0003-6951 |
Popis: | We have demonstrated high-sensitivity detection of bacteria using an array of bulk micromachined resonant cantilevers. The biological sensor is a micromechanical oscillator that consists of an array of silicon-nitride cantilevers with an immobilized antibody layer on the surface of the resonator. Measured resonant frequency shift as a function of the additional cell loading was observed and correlated to the mass of the specifically bound Escherichia coli O157:H7 cells. Deposition and subsequent detection of E. coli cells was achieved under ambient conditions. |
Databáze: | OpenAIRE |
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