Mechanical resonant immunospecific biological detector

Autor:	David A. Czaplewski, Harold G. Craighead, Pavel Neuzil, Carl A. Batt, Bojan Ilic, C. Campagnolo
Rok vydání:	2000
Předmět:	Materials science Cantilever Physics and Astronomy (miscellaneous) business.industry Detector Analytical chemistry Frequency shift Resonator Surface micromachining Deposition (phase transition) Optoelectronics business Biosensor Layer (electronics)
Zdroj:	Applied Physics Letters. 77:450-452
ISSN:	1077-3118 0003-6951
Popis:	We have demonstrated high-sensitivity detection of bacteria using an array of bulk micromachined resonant cantilevers. The biological sensor is a micromechanical oscillator that consists of an array of silicon-nitride cantilevers with an immobilized antibody layer on the surface of the resonator. Measured resonant frequency shift as a function of the additional cell loading was observed and correlated to the mass of the specifically bound Escherichia coli O157:H7 cells. Deposition and subsequent detection of E. coli cells was achieved under ambient conditions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::49f0a18d819b72260717d784de3ea80d https://doi.org/10.1063/1.127006 Zobrazit plný text záznamu