The impact of external stress factors on hippocampus volume during antidepressant treatment
| Autor: | Ingrid Tonhajzerova, Dusan Dobrota, I Hrtanek, D Cesnekova, Igor Ondrejka, Marian Grendar, M. Bittsansky, M. Oppa, Ivan Farsky, P. Hutka, Kamil Zelenak |
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| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty medicine.diagnostic_test business.industry Venlafaxine Magnetic resonance imaging Hippocampal formation medicine.disease 030227 psychiatry 03 medical and health sciences Psychiatry and Mental health 0302 clinical medicine Holmes and Rahe stress scale Internal medicine medicine Antidepressant Major depressive disorder Hippocampus (mythology) 030212 general & internal medicine business Depression (differential diagnoses) medicine.drug |
| Zdroj: | The European Journal of Psychiatry. 35:92-98 |
| ISSN: | 0213-6163 |
| DOI: | 10.1016/j.ejpsy.2020.12.004 |
| Popis: | Background and objectives Magnetic resonance imaging (MRI) studies suggest that depression is associated with volumetric hippocampal changes. Investigations of these structures during antidepressant therapy is therefore important, however, volumetric studies are rare in this case. We aimed to study the effect of AD treatment on volumetric changes in hippocampus depending on stress factors in depressive patients. Methods Thirty patients with major depressive disorder (MDD) underwent MRI of the brain on the day of admission and at the time of stabilization of acute depressive symptomatology by venlafaxine. The presence of long-lasting stress factors in these patients was investigated by the social readjustment rating scale questionnaire. Results No significant differences were found in hippocampi volumes before and after venlafaxine treatment. However, regression analysis revealed significant positive relation between stress factors and volumetric hippocampus change during AD treatment. Conclusion It seems that antidepressant treatment by venlafaxine could be more suitable in the MDD patients with presence of stress-factors. |
| Databáze: | OpenAIRE |
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