Synergic effect of hydrogen bonding and dipole repulsion in the ring-closing metathesis of N-homoallyl-2-(hydroxymethyl)acrylamides

Autor:	Pengbo Lu, Yuehai Shen, Zhongxian Liu
Rok vydání:	2019
Předmět:	010405 organic chemistry Hydrogen bond Chemistry Organic Chemistry 010402 general chemistry Metathesis 01 natural sciences Biochemistry Carbonyl group 0104 chemical sciences Dipole chemistry.chemical_compound Ring-closing metathesis Drug Discovery Polymer chemistry Hydroxymethyl
Zdroj:	Tetrahedron Letters. 60:1808-1810
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2019.06.011
Popis:	This study reveals that the Ru-catalyzed ring-closing metathesis of N -homoallyl-2-(hydroxymethyl)acrylamides is promoted by substrate-catalyst hydrogen bonding as well as dipole repulsion between the electron-rich side-chain and the carbonyl group, providing clues for designing effective synthetic routes towards 5,6-dihydro-2(1 H )-pyridinones.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::49e6c142026b6f8f2e6f592988218492 https://doi.org/10.1016/j.tetlet.2019.06.011 Zobrazit plný text záznamu Full Text from ScienceDirect