| Autor: |
Sandra Melnick, Jane Sanvffle, Michelle Hardy, David Townley, William Valuer, Karen Irvin, Melanie A. Thompson, James D. Neaton, Amy Morris, Joyce A. Korvick, James H. Sampson, Thomas A. Louis, Nancy Kimmel, Kathryn Anastos, Diane Mastro-Polak, Linnea Capps, Renee Renzetti, Dean L. Winslow, Jeffrey Kocher, Norman Markowitz, Jones Kumi, Carol A. Mesard, Renslow Sherer, Arlene Bincsik, Mordechai Bar, Phyllis Simmons, Annemarie Sheridan, Rita Verheggen, Jerome Ernst, Janet Y. Lee, Tim Brelje, Jack Ebright, Kathleen Clanon, Jill Hutchinson, Evelyn Fisher, Joel Godbey, Evelyn M. Rodriguez, Bea Morris, William Owen, Lawrence Gernon, Lawrence S. Brown, Norma Martinez, Marcia Carlyn, Mark Loveless, Jan Walker, Luis Fuentes, Alain DuChene, Lawrence R. Deyton, William J. Holloway, Susan Szabo, Karen Swanson, Michael J. Grodesky, Ami Labriola, Kurt Link, Roberta Luskin-Hawk, Thomas M. Kerkering, Cathy Pollard, Ramon A. Torres, Cheryl Lackman, Mary Foulkes, Victoria M. Taylor, Louis Saravolatz, Elizabeth Doramajian, Paula Schuman, Carol Brosgart, Stanley Johns, Steven Weisholtz, Micheal J. Hickson, Greg Thompson, Scott Jp, Sue Pablovich, Joan E. Gans, David Hillman, Elizabeth Finley, Catherine Salveson, Randall Reves, Jilleen Braithwaite, David Moore, David L. Cohn, Carol Webster, Cheryl Guity, Colleen Fairclough, Cynthia L. Gibert, Lawrence R. Crane, Terri Creagh, Deborah Wentworth, Wafaa El-Sadr, Lawrence Deyton, David Blatt, Jacquelyn Ellison |
| Rok vydání: |
1994 |
| Předmět: |
|
| Zdroj: |
JAMA. 272:1915 |
| ISSN: |
0098-7484 |
| DOI: |
10.1001/jama.1994.03520240043039 |
| Popis: |
Objective. —To compare disease progression and mortality between women and men infected with human immunodeficiency virus (HIV). Design. —Multicenter cohort. Setting. —Seventeen community-based centers participating in the Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA). Patients. —A total of 768 women and 3779 men enrolled in one or more of 11 protocols between September 7, 1990, and September 30, 1993. Main Outcome Measures. —Survival and opportunistic events. Results. —The median CD4 + cell count at enrollment into the cohort was 0.240 ×10 9 /L (240/μL) for women and 0.137 ×10 9 /L for men ( P P =.01) and for disease progression (including death) was 0.97 (95% CI, 0.82 to 1.15; P =.72). Women were at increased risk for bacterial pneumonia (RR, 1.38; 95% CI, 1.05 to 1.92) and at reduced risk for the development of Kaposi's sarcoma (RR, 0.16; 95% CI, 0.04 to 0.65) and oral hairy leukoplakia (RR, 0.54; 95% CI, 0.31 to 0.94). The increased risk of death and bacterial pneumonia for women compared with men was primarily evident among those with a history of injection drug use (RR, 1.68 for death, 95% CI, 1.20 to 2.35, P =.003; RR, 1.53 for bacterial pneumonia, 95% CI, 1.03 to 2.29, P =.04). Among patients without a history of disease progression at entry, death was the first event reported for more women than men (27.5% vs 12.2%). Conclusions. —Compared with men, HIV-infected women in the CPCRA were at increased risk of death but not disease progression. Risks of most incident opportunistic diseases were similar for women and men; however, women were at an increased risk of bacterial pneumonia. These findings may reflect differential access to health care and standard treatments or different socioeconomic status and social support for women compared with men. ( JAMA . 1994;272:1915-1921) |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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