Two new C21 steroidal glycosides isolated from Cynanchum komarovii
| Autor: | Dan Zhao, Shan-Shan Su, Shao-Fei Chen, Yue-Hu Pei, Guang-Yue Su, Yu-Bo Wang, Gang Chen, Xiao-Jie Lu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
biology
Steroidal glycosides 010405 organic chemistry Stereochemistry Positive control General Medicine Cynanchum biology.organism_classification 01 natural sciences 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Aglycone Complementary and alternative medicine chemistry Drug Discovery Ic50 values Acid hydrolysis Cynanchum komarovii Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Chinese Journal of Natural Medicines. 16:610-614 |
| ISSN: | 1875-5364 |
| DOI: | 10.1016/s1875-5364(18)30098-0 |
| Popis: | The present study was designed to further investigate the C21 steroidal glycosides in Cynanchum plants. Two new steroidal glycosides based on a 13, 14:14, 15-disecopregnane-type aglycone, komaroside P (1) and komaroside Q (2), together with three known compounds (3-5) were isolated from the whole herbs of Cynanchum komarovii. The aglycones of compounds 1 and 2 were two new disecopregnane. Their structures were elucidated on the basis of 1D, 2D NMR spectroscopic data and acid hydrolysis. All the compounds (1-5) showed potent inhibitory activities against human leukemia cell lines (HL-60) with IC50 values ranging from 16.6 to 26.3 μmol·L-1, compared to the positive control 5-fluorouracil (6.4 μmol·L-1). |
| Databáze: | OpenAIRE |
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