The Interaction of Water-Soluble Pillar[5]Arenes Containing Amide and Ammonium Fragments with Lipid Bilayer
| Autor: | Elena V. Gruzdeva, Polina V. Skvortsova, D. N. Shurpik, Ivan I. Stoikov, Vladimir V. Klochkov, Bulat I. Khairutdinov, Dzhigangir A. Faizullin, Pavel V. Zelenikhin, Vladimir G. Evtugyn |
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| Rok vydání: | 2018 |
| Předmět: |
Liposome
010405 organic chemistry Biomedical Engineering Bioengineering 010402 general chemistry 01 natural sciences 0104 chemical sciences law.invention Ames test chemistry.chemical_compound chemistry law Amide Polymer chemistry Ammonium Titration sense organs Turbidimetry Electron microscope Lipid bilayer |
| Zdroj: | BioNanoScience. 8:888-894 |
| ISSN: | 2191-1649 2191-1630 |
| DOI: | 10.1007/s12668-018-0532-5 |
| Popis: | The absence of toxic properties and genotoxic activity was shown for water-soluble pillar[5]arenes containing amide and ammonium fragments. There was no induced mutation associated with the substitution of base pairs in the Ames test. Using the methods of turbidimetry and transmitting electron microscopy (TEM), the interaction of the macrocycle with the surface of lipid bilayer in the liquid crystalline state was established. DLS detected the appearance of larger particles upon titration of liposome suspension with pillar[5]arene 3. TEM confirms an increase in the average diameter of liposomes in the presence of the macrocycle which may result from liposome fusion. |
| Databáze: | OpenAIRE |
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