Aerobic exercise reduces asthma phenotype through inhibition of SOCS-JAK-STAT signaling in airway epithelium
| Autor: | Ana Paula Ligeiro de Oliveira, Jefferson Comin Jonco Aquino-Junior, Nicole Cristine Rigonato-Oliveira, Auriléia Aparecida-Brito, Rodolfo de Paula Vieira, Manoel Carneiro Oliveira-Junior, Erasmo Assumpção Neto, Gabriel de Moraes, Adilson Santos Andrade-Sousa, Ana Roberta Almeida-Oliveira |
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| Rok vydání: | 2015 |
| Předmět: |
House dust mite
medicine.medical_specialty biology business.industry medicine.medical_treatment biology.organism_classification medicine.disease stat respiratory tract diseases Cytokine Immunology STAT protein Physical therapy medicine Respiratory epithelium Aerobic exercise Janus kinase business Asthma |
| Zdroj: | 1.2 Rehabilitation and Chronic Care. |
| DOI: | 10.1183/13993003.congress-2015.pa2211 |
| Popis: | Airway epithelium presents a key role in asthma pathogenesis. A complex signaling involving suppressor of cytokine signaling protein family (SOCS), janus kinase (JAK) and signal transducer and activator of transcription (STAT) modulates asthma. Aerobic exercise (AE) reduces airway inflammation, but the role of SOCS-JAK-STAT mediating anti-inflammatory effects of exercise is unknown. Thus, 40 C57Bl/6 male mice were distributed in Control (Co), Exercise (Ex), Asthma (As) and Asthma+Exercise (As+Ex) groups. House dust mite (HDM - Dermatophagoides pteronyssinus; 100ug/mouse) was orotracheally administered once a week on days 0, 7, 14, 21, 28, 35 and 42. Low intensity treadmill aerobic training (1h/session, 5x/week, 4 weeks) was performed, beginning after the establishment of airway inflammation (day 17). Animals were euthanized on day 45. The results demonstrated that AE reduced HDM-increased total leukocytes (p |
| Databáze: | OpenAIRE |
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