[Bmim]HSO4-Catalyzed Synthesis of Tetrasubstituted Imidazoles as Potential Mutant Isocitrate Dehydrogenase 1 Inhibitors

Autor:	M. Shekarchi, Farahnaz K. Behbahani
Rok vydání:	2020
Předmět:	chemistry.chemical_compound Isocitrate dehydrogenase chemistry Aryl Organic Chemistry Ionic liquid Mutant Substituent Benzil Ammonium acetate Combinatorial chemistry Catalysis
Zdroj:	Russian Journal of Organic Chemistry. 56:894-900
ISSN:	1608-3393 1070-4280
Popis:	An ecofriendly, simple, and efficient one-pot protocol has been developed for the synthesis of 1,2,4,5-tetrasubstituted imidazoles by the reaction of benzil, aryl aldehydes, aliphatic or aromatic amines, and ammonium acetate, catalyzed by the acidic halogen-free ionic liquid [bmim]HSO4 under solvent-free conditions. The advantages of the proposed protocol include high yields, short reaction time, operational simplicity, and recyclability of the catalyst. Eight previously unknown tetrasubstituted imidazoles were synthesized, among which those bearing a cyclopropyl substituent on N1 can be considered as potential mutant isocitrate dehydrogenase 1 (IDH1) inhibitors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::49c0a7eb45d8da8cf60917b96acca87c https://doi.org/10.1134/s1070428020050243 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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