Kainate-Induced Degeneration of Hippocampal Neurons. Protective Effect of Activation of the Endocannabinoid System
| Autor: | S. S. Khutsian, Valentina F. Kitchigina, R. Ya. Gordon, I. B. Mikheeva, Liubov Shubina |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Kainic acid
Dentate gyrus Neurodegeneration Hippocampus Kainate receptor General Medicine Hippocampal formation URB597 medicine.disease Endocannabinoid system General Biochemistry Genetics and Molecular Biology Cell biology chemistry.chemical_compound nervous system chemistry medicine lipids (amino acids peptides and proteins) |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 171:327-332 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-021-05221-4 |
| Popis: | We studied the prolonged action of kainic acid on glutamatergic neurons in the dorsal hippocampus and the endocannabinoid-dependent protection against neurodegeneration. The pyramidal neurons of the CA3 field of the hippocampus, as well as granular and mossy cells of the dentate gyrus were examined. Light and electron microscopy revealed substantial damage to the components of the protein-synthesizing (rough endoplasmic reticulum, Golgi apparatus, and polyribosomes) and catabolic (lysosomes, autophagosomes, multivesicular structures, and lipofuscin formations) systems in all cells. Pyramidal and mossy neurons die mainly by the necrotic pathway. The death of granular cells occurred through both apoptosis and necrosis. The most vulnerable cells are mossy neurons located in the hilus. Activation of the endocannabinoid system induced by intracerebral injection of URB597, an inhibitor of degradation of endocannabinoid anandamide, protected the normal structure of the hippocampus and prevented neuronal damage and death induced by KA. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink