Synthesis and Anti-HIV Activity of New 6-Thioarylpyrimidines and Related Compounds

Autor:	Saman H. Noori, Thilo Schuppler, Yaseen A. Al-Soud, Iman A. Al-Masoudi, Najim A. Al-Masoudi
Rok vydání:	2008
Předmět:	Inorganic Chemistry Anti hiv activity Chemistry Stereochemistry Organic Chemistry Biochemistry Reverse transcriptase
Zdroj:	Phosphorus, Sulfur, and Silicon and the Related Elements. 183:1571-1583
ISSN:	1563-5325 1042-6507
DOI:	10.1080/10426500701693453
Popis:	A series of new 5-nitro- and 5-amino-6-arylsulfanyl-1-propyl-1H-pyrimidin-2,4-diones (4–9) were synthesized with the aim to develop new non-nucleoside reverse transcriptase inhibitors (NNRTIs). Similarly, 6-arylsulfanyl-1,3-dimethyl-5-nitro-1H-pyrimidin-2,4-diones (12–15) were prepared from 10. A new 2-amino-2-phenyl-7-phenylsulfanyl-imidazo[1,2-a]pyrimidin-5-one (18) has been synthesized from reaction of 17 with α -bromoacetophenone in the presence of NaH. The newly synthesized compounds were evaluated for their anti HIV-1 and HIV-2 activity in MT-4 cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::49ba44dfc5fa194feb76674ba385486f https://doi.org/10.1080/10426500701693453 Zobrazit plný text záznamu