N-Methyltyramine and N,O-Dimethyltyramine Synthesis via Intermediate 4-Methoxyphenyl-N-methyltioacetamide

Autor:	Oleg N. Tolkachev, Alexander N. Shchavlinskii, Vladimir N. Bulavka, Russian Federation
Rok vydání:	1999
Předmět:	chemistry.chemical_classification N-methylthioacetamide chemistry.chemical_compound Nickel Sodium borohydride N-Methyltyramine Sulfide chemistry Phosphorus chemistry.chemical_element Lithium aluminium hydride Medicinal chemistry Alkyl
Zdroj:	Proceedings of The 3rd International Electronic Conference on Synthetic Organic Chemistry.
Popis:	N-Methyltyramine and its alkyl or benzyl ethers are common intermediate products in the syntheses of narwedine, and galanthamine alkaloids [1-8]. They are usually produced from the corresponding arylacetamides by lithium aluminium hydride reduction. In order to avoid application of inflammable lithium aluminium hydride bulgarian scientists have transformed arylacetamide to arylthioacetamide with phosphorus (V) sulfide with following reduction of arylthioacetamide with complex sodium borohydride nickel or cobalt chloride agents [7, 8].
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::49b952b118d157347ac0523062e43873 https://doi.org/10.3390/ecsoc-3-01731 Zobrazit plný text záznamu