| Autor: |
Michael J. Seckl, Eric O. Aboagye, Gordon W. Stamp, Nick R. Lemoine, Bradley Spencer-Dene, Richard Poulsom, Emma Nye, Rosemary E. Jeffery, John Latigo, Olivier E. Pardo |
| Rok vydání: |
2023 |
| DOI: |
10.1158/0008-5472.c.6499953.v1 |
| Popis: |
Lung cancer is the commonest cancer killer. Small cell lung cancer (SCLC) is initially chemosensitive, but rapidly relapses in a chemoresistant form with an overall survival of 6 months in 50% of mice. These effects were not a consequence of disrupted tumor vasculature but instead correlated with increased apoptosis (caspase 3 and cytokeratin 18 cleavage) in excised tumors. Moreover, in vivo imaging with 3′-deoxy-3′-[18F]fluorothymidine–positron emission tomography ([18F]FLT-PET) showed decreased intratumoral proliferation in live animals treated with the compound at 7 to 14 days. Our results suggest that clinical trials of FGFR inhibitors should be undertaken in patients with SCLC and that [18F]FLT-PET imaging could provide early in vivo evidence of response. [Cancer Res 2009;69(22):8645–51] |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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