| Popis: |
A major function of dendritic cells (DC) is the initiation of primary immune response in T cells; immature DC (imDC) pick up antigen at the skin or many mucosal surfaces and, after receiving appropriate maturation signal, migrate to lymphoid organs and activate naive T cells [20]. Monocyte–derived cytokines IL-1 and TNF–a, as well as monocyte-conditioned medium (MCM), were reported to provide such signals for maturation of DC [18]. During acute inflammation, monocytes (Mo) emigrate from the bloodstream to peripheral tissues in response to molecular signals that indicate injury or infection. At the inflammatory site, Mo are activated by wide variety of signals involving a number of adhesion molecule-counterreceptor interactions and, differentiate into macrophages [19]. Since both DC and monocytes/macrophages are present at the site of inflammation [10], we investigated a possible interaction between these cells. |
