MRI-Contrasting System Based on Water-Soluble Fullerene/Gd-Metallofullerene Mixture
| Autor: | V. P. Sedov, Vasily T. Lebedev, A. L. Shakhmin, V. A. Shilin, S. G. Kolesnik, T. O. Artamonova, M. A. Khodorkovsky, V. S. Kozlov, E. V. Tsyrlina, S. G. Konnikov, V. V. Shamanin, P. I. Krzhivitsky, E. Yu. Melenevskaya, M. V. Zamorianskaya, Yu. S. Grushko |
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| Rok vydání: | 2010 |
| Předmět: |
Fullerene
Chemistry Gadolinium Organic Chemistry Extraction (chemistry) chemistry.chemical_element Small-angle neutron scattering Atomic and Molecular Physics and Optics Hydroxylation chemistry.chemical_compound Water soluble Metallofullerene General Materials Science Physical and Theoretical Chemistry Nuclear chemistry |
| Zdroj: | Fullerenes, Nanotubes and Carbon Nanostructures. 18:417-421 |
| ISSN: | 1536-4046 1536-383X |
| Popis: | The gadolinium endometallofullerene/empty fullerene hydroxylated mixtures were prepared and studied as MRI-contrasting agents. The mixtures were prepared with metallofullerene enrichment of more than 80 mol.% by simple liquid extraction. The hydroxylation was performed by H2O2 oxidation at elevated temperature. Nanoaggregation of mixed fullerenes in water solution was studied by SANS. It was observed that at pH = 7 the cluster correlation diameter is 25 nm. NMR tomography in-vivo reveals that contrasting action of hydroxylated gadofullerene mixtures is 15–30 times its commercial “Gadovist” contrasting agent. |
| Databáze: | OpenAIRE |
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