Radiopharmaceuticals Based on Alpha Emitters: Preparation, Properties, and Application

Autor:	Bogdan L. Garashchenko, R. Yu. Yakovlev, V. A. Korsakova
Rok vydání:	2018
Předmět:	Physics 03 medical and health sciences Nuclear and High Energy Physics 0302 clinical medicine 030220 oncology & carcinogenesis Radiochemistry Atomic and Molecular Physics and Optics 030218 nuclear medicine & medical imaging
Zdroj:	Physics of Atomic Nuclei. 81:1515-1525
ISSN:	1562-692X 1063-7788
DOI:	10.1134/s1063778818100071
Popis:	In this review, the problems of the development of radiopharmaceuticals (RPs) based on alphaemitting radionuclides are discussed. The prospects of application of the radionuclides 227Th, 225Ac, 223Ra, 213Bi, 212Pb/212Bi, 212Bi, 211At, and 149Tb are estimated in the aspect of their physicochemical properties, such as half-life, properties of daughter radionuclides, and complexing ability. The methods used for the production of radionuclides and their industrial availability are considered. Some examples of radionuclide complexes with ligands and nanoparticles for targeted delivery are presented. The results of medical trials for RPs based on alpha emitters are given.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::49aa719350566089f70bb1e549821813 https://doi.org/10.1134/s1063778818100071 Zobrazit plný text záznamu Plný text ve formátu PDF