FORMULATION AND EVALUATION OF CARICA PAPAYA NANOEMULSION FOR TREATMENT OF DENGUE AND THROMBOCYTOPENIA

Autor:	Manoj Kumar Sagar, Vishakha Jaiswal, Sachin Kumar, Suraj Mandal
Rok vydání:	2021
Předmět:	biology Traditional medicine Chemistry medicine Plant Science Carica biology.organism_classification medicine.disease Dengue fever
Zdroj:	PLANT ARCHIVES. 21
ISSN:	2581-6063 0972-5210
DOI:	10.51470/plantarchives.2021.v21.no1.179
Popis:	Aim of the current research work was to enhance availability of Carica papaya to through the oral route using nanoemulsion approach. The attempt was made to develop a nanoemulsion formulation of Carica papaya and its evaluation in the treatment of dengue as well as thrombocytopenia. Nanoemulsion is clear, heterogeneous emulsion (of droplet size 50-200 nm) consists of surfactant/co-surfactant (Smix), oil, water and drug. Different components were selected on the basis of solubility of Carica papaya in different oils. Tween 20 and polyethylene glycol (PEG-400) was selected as surfactant/co-surfactant, while oleic acid used as an oil phase in nanoemulsion. Nanoemulsion formulations are physically identified on the basis of phase diagram. These are characterized on the basis of viscosity, conductivity, refractive index morphological and stability evaluation etc. This combination of Smix and oil ratio had sufficient capacity to load Carica papaya leaf powder (drug) which yielded nano emulsification in aqueous media and produced nanoemulsion with droplet size (63.37nm).According to all evaluation parameters, formulation number-4 (F4) showed the promising prospective on the basis of particle size range
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::49a73d8ddba173a1a630e57787a210f6 https://doi.org/10.51470/plantarchives.2021.v21.no1.179 Zobrazit plný text záznamu