Slow-Release Plastic Pellets (Elvax) for Localized In Situ Treatments of Mouse and Rat Mammary Tissue

Autor:	Charles W. Daniel, Gary B. Silberstein
Rok vydání:	2000
Předmět:	In situ Pathology medicine.medical_specialty Materials science Mammary gland Mammary tissue Matrix (biology) Cell biology Paracrine signalling medicine.anatomical_structure In vivo medicine Autocrine signalling Hormone
Zdroj:	Methods in Mammary Gland Biology and Breast Cancer Research ISBN: 9781461369271
DOI:	10.1007/978-1-4615-4295-7_8
Popis:	The need to define the actions of paracrine and autocrine signaling factors against a background of systemic hormones led to the development of the slow-release implant technique. Elvax40P® is an ethylene vinyl acetate copolymer. Formed into a matrix containing test materials such as hormones or growth factors, Elvax releases metered amounts and can be used to treat small zones within the mammary gland. Importantly, Elvax is generally nondenaturing to proteins and steroids and does not elicit a tissue response. To date, Elvax experiments have been used to help define the in vivo roles of a variety of growth factors and hormones. Here we describe the fabrication and surgical techniques necessary to use this material.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::49a45c9c1de909bb477c8cb8bc7af366 https://doi.org/10.1007/978-1-4615-4295-7_8 Zobrazit plný text záznamu