Genetic Reconstruction of One Hereditary Nonpolyposis Colorectal Cancer History with Multiple Initiations of the Disease

Autor:	Alexey V. Gulyaev, Kazimir M. Pozharisski, Vladislav A. Lanzov, Olga A. Vostrukhina, Tatyana A. Shtam
Rok vydání:	2008
Předmět:	Oncology medicine.medical_specialty Colorectal cancer business.industry Disease medicine.disease medicine.disease_cause MLH1 Primary lesion Genetic pathways Internal medicine medicine Retrospective analysis business Carcinogenesis Gene
Zdroj:	The Open Environmental & Biological Monitoring Journal. 1:43-47
ISSN:	1875-0400
Popis:	The scheme of accumulation of genetic alterations in a long-term case of hereditary nonpolyposis colorectal cancer (HNPCC) was reconstructed by the retrospective analysis of postoperative tissue materials. This unique case re- sulted from a primary lesion in MLH1 gene and revealed two genetic pathways of carcinogenesis in tumors separated by lifetime and localization.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::49a24e6c4b2a9b319580a6ca3e2b3f46 https://doi.org/10.2174/1875040000801010043 Zobrazit plný text záznamu